REMARKS
Claims 19-22, 26, 33-35 and 39-45 are pending in the instant application. Claims
23-25, 27-32 and 36-38 are canceled. Reconsideration of the currently pending claims in
light of the comments presented below is respectfully requested.
35 U.S.C. § 112, Second Paragraph
Claims 25 and 27-31 stand rejected under § 1 12, second paragraph, as being
indefinite for failing to particularly point out and distinctly claim the subject matter
which the applicant regards as the invention. In light of the amendments presented
above, Applicants respectfully request withdrawal of each of the rejection under 35
U.S.C. § 1 12, second paragraph.
35 U.S.C. § 102(e)
Claims 19-31 and 33-40 stand rejected under 102(e) as anticipated by Kayyem et
al., U.S. Patent No. 6,096,273 ("Kayyem"). In particular, the Examiner asserts that
Kayyem teaches nucleic acids attached to electrodes via insulators, as is currently
claimed in the instant application. The Examiner bases her contention on the following
statement found at column 24, lines 59-61 :
The passivation agents are generally attached to the electrode in the same manner
as the conductive oligomer and may use the same "A" linker as defined above.
The "A" linker is defined at Column 21, lines 29-35:
In this embodiment, A is a linker or an atom. The choice of "A" will
depend in part on the characteristics of the electrode. Thus, for example,
A may be a sulfur moiety when a gold electrode is used. Alternatively,
when metal oxide electrodes are used, A may be a silicon (silane) moiety
attached to the oxygen of the oxide (see for example Chen et al., Langmuir
10:3332-3337(1994).
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Accordingly, "A" is merely the atom, or atoms, used to attach either a conductive
polymer or a passivation agent' to an electrode.
For an anticipation rejection under 35 U.S.C. §102(e) to be proper, a single
reference must expressly or inherently disclose each and every element of a claim. In re
Paulsen, 31 USPQ2d 1671, 1673 (Fed. Cir. 1994); MPEP § 2131 (citing Richardson v.
Suzuki Motor Co., 9 USPQ2d 1913, 1920 (Fed. Cir. 1989). As pointed out above, the
Examiner has only shown that conductive oligomers and passivation agents may be
attached to electrodes in the same manner. The Examiner has not pointed to any
disclosure in Kayyem that teaches nucleic acids attached to electrodes via insulators.
Accordingly, the Examiner has not carried her burden under § 102(e), and therefore
Applicants respectfully reiterate their request for withdrawal of the rejection.
Double Patenting
U.S. Patent No. 6,096,273
Claims 19-31 and 33-40 stand rejected under the judicially created doctrine of
obviousness-type double patenting as being unpatentable over Claims 1-34 of U.S. Patent
6,096,273. Applicants respectfully traverse the propriety of the rejection. In particular,
the Examiner's position appears to be that since the claimed compositions utilize the
phrase "comprising", the Examiner is therefore able to go through the specification and
find additional components that would render the claimed compositions as "obvious
variations" over the '229 patent. This is incorrect. All of the claims in the '229 patent are
drawn to the use of conductive oligomers to attach nucleic acids to the electrodes. The
present claims are directed to the use of insulators for attachment of the nucleic acids to
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the electrodes. An "insulator" is not an obvious variation over a "conductive oligomer".
Accordingly, it would not have been obvious to one of ordinary skill in the art at the time
the invention was made to modify the claimed composition to achieve the instant
invention. Thus, Applicants respectfully request withdrawal of the instant rejection.
U.S. Patent No. 6.248.229
Claims 19-31 and 33-40 stand rejected under the judicially created doctrine of
obviousness-type double patenting as being unpatentable over Claims 11-21 of U.S.
Patent 6,248,229. Applicants again respectfully traverse the propriety of this rejection,
however in the interest of expediting prosecution, and since the '229 patent and the
present application share the same priority date, a terminal disclaimer listing U.S. Patent
No. 6,248,229 is submitted herewith. Accordingly, Applicant respectfully requests
withdrawal of the double patenting rejection based on U.S. Patent No. 6,248,229.
U28957_1.DOC
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CONCLUSION
Applicants respectfully submit that the claims are in condition for allowance and
early notification to that effect is respectfully requested. Please direct any calls in
connection with this application to the undersigned attorney at (415) 781-1989.
Respectfully submitted,
DORSEY & WHITNEY LLP
Dated:
T3,
Four Embarcadero Center
Suite 3400
San Francisco, California 941 1 1-4187
Telephone: (415)781-1989
Fax No. (415)398-3249
By:
Steven P. Lendaris, Reg. No 53,202
for
Robin M. Silva, Reg. No. 38,304
Filed under 37 C.F.R. § 1.34(a)
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